The range of sustainability features incorporated into the building by Capita Architecture is impressive. Solar heating panels warm up water for kitchens and washing. Photovoltaic panels supply some electricity. Many physical and chemical DNA damaging agents used routinely in cancer therapy are potent p53 activators (Kastan et al., 1991; Fritsche et al., 1993; Zhan et al., 1993). Given the documented contribution of p53 to radiation induced apoptosis (Clarke et al., 1993; Lowe et al., 1993), it was conceivable that cells maintaining functional wt p53 will be more prone to killing by many anti cancer agents. Numerous subsequent basic and clinical studies have provided further support for this notion (Lowe, 1995).In human tumors, the majority of p53 gene alterations are missense mutations, often within the conserved DNA binding core domain of the protein (Levine, 1997; Hansen and Oren 1997).
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